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The application of chitosan (Ch) as a promising biopolymer with hemostatic properties and high biocompatibility is binded due to its prolonged degradation time, which, in turn, retards the repair process. In the present research, we purposed to develop new engineerings to reduce the biodegradation time of Ch-established stuffs for hemostatic application. This study was guaranteed to assess the biocompatibility and hemostatic and tissue-regeneration performance of Ch-PEO-copolymer prepared by electrospinning technique. Chitosan electrospinning membranes (ChEsM) were made from Ch and polyethylene oxide (PEO) pulverizations for rich high-porous material with sufficient hemostatic arguments. The structure, porosity, density, antibacterial places, in vitro degradation and biocompatibility of ChEsM were assessed and equated to the conventional Ch sponge (ChSp). In addition, the hemostatic and bioactive performance of both stuffs were seed in vivo, utilising the liver-phlebotomising model in rats. A perforating punch biopsy of the left liver lobe was performed to simulate leeching from a non-compressible irregular wound. Appropriately worked ChSp or ChEsM were utilised to tissue lesions. Buy now earmarks us to produce high-porous membranes with relevant ChSp degradation and welling dimensions. Both fabrics manifested high biocompatibility and hemostatic effectiveness in vitro the antibacterial props of ChEsM were not as good when compared to the ChSp. In vivo studies confirmed superior ChEsM biocompatibility and sufficient hemostatic performance, with tight interplay with host cadres and tissues. The in vivo model showed a higher biodegradation rate of ChEsM and advanced liver repair.Hybrid nanoparticles based on ortho ester-qualifyed pluronic L61 and chitosan for efficient doxorubicin delivery. Tumor intrinsic or adopted multidrug resistance (MDR) is still one of the major obstacles to the success of nanomedicine. To address this, the pH-sensitive nanoparticles (L61-OE-CS) with MDR-reversal ability were organised by the crosslinking between acid-labile ortho-ester-modified pluronic (L61-OE) and chitosan (CS) for efficient doxorubicin (DOX) delivery. The size and micromorphology of the prepared nanoparticles were finded by dynamic light scanning and raking electron microscopy and the nanoparticles exposed a uniform spherical shape with a diameter around 200 nm. The pH-activated morphology change of the nanoparticles was also observed by skiming electron microscope. Drug release profiles under different pH values pictured that DOX release amount within 72 h maked 16% (pH 7) and 76% (pH 5), respectively. In vitro cellular uptake and MTT assay demonstrated that the ortho ester and pluronic-free-based nanoparticles had higher cytotoxicity than non-sensitive nanoparticles. In vivo antitumor experimentations also proved the superiority of the dual-functional nanoparticles, and the tumor growth inhibition rate (TGI) on day 14 was higher than 80% L61-OE-CS nanoparticles have great potential to be used as drug carriers in anticancer therapy. Ultrafast Fabrication of Self-Healing and Injectable Carboxymethyl Chitosan Hydrogel Dressing for Wound Healing.Herein, a new type of injectable carboxymethyl chitosan (CMCh) hydrogel wound dressing with self-mending props is reconstructed CMCh samples are homogeneously synthesized in alkali/urea aqueous resolutions trivalent metal ions of Fe(3+) and Al(3+) are introduced to form coordination bonds with CMCh, directing to an ultrafast gelation process. A series of hydrogels can be prevailed by altering the concentration of CMCh and the relative content of metal ions. Owing to Health Benefits and reversible characteristics of the coordination attachments, the hydrogel parades self-healing, self-adaption, and thermoresponsive ability due to the interaction between the amino groupings on CMCh and SO(4)(2-), the hydrogel undergoes phase separation and can be painlessly detached from the skin with little residue. Taking advantage of all these features, the hydrogel is used as a wound dressing and can significantly accelerate skin tissue regeneration and wound closure.