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CONCLUSION: NMCM hydrogel can promote chondrocytes proliferation, down regulate chondrocyte catabolism, resist oxidative stress, protect chondrocytes from cartilage injury, and promote cartilage repair.Quarternized chitosan/quercetin/polyacrylamide semi-interpenetrating network hydrogel with recoverability, toughness and antibacterial dimensions for wound healing.Antibiotic abuse has amazed enormous burdens on patients and healthcare schemes. Hence, the design and development of non-antibiotic wound bandagings to meet clinical demand are urgently desired there rests one of the checks to hydrogel wound groomings that mixed with good recoverability, toughness, and excellent antibacterial places a series of semi-interpenetrating network (semi-IPN) hydrogels with exceptional mechanical performance and remarkable antibacterial activity based on quaternized chitosan (QCS) and polyacrylamide (PAM) were developed using a one-pot method. Additionally, Order immediately of semi-IPN hydrogel against S. aureus and E. coli was heightened by integrating it with quercetin (QT). Selenium -IPN hydrogels also exhibited high recoverability and toughness, outstanding liquid absorbability (the welling ratio reached 565 ± 12 %), and a satisfying water vapor transmission rate the semi-IPN hydrogels introduced ideal hemocompatibility and cytocompatibility. These high-elastic hydrogels are predicting nominees for potential coverings in wound dressing, tissue repair, chronic wound care, as well as other biomedical battlefields.Graphene Oxide/Chitosan Injectable Composite Hydrogel for Controlled Release of Doxorubicin: An Approach for Enhanced Intratumoral Delivery.Intratumoral (IT) injection of chemotherapeutics into needle-accessible solid tumors can directly localize the anticancer drug in the tumor site, thus increasing its local bioavailability and subduing its undesirable events compared to systemic administration. In this study, graphene oxide (GO)-based chitosan/β-glycerophosphate (CS/GP) thermosensitive injectable composite hydrogels (CH) were educated and optimised for the localised assured delivery of doxorubicin (DOX). A quality-by-design (QbD) approach was used to study the individual and combined effects of several formulation variables to produce optimal DOX-loaded GO/CS/GP CH with predetermined features, admiting gelation time, injectability, porosity, and tumescing capacity. The surface morphology of the optimal formulation (DOX/opt CH), chemical interaction between its ingredients and in vitro release of DOX in comparison to GO-free CS/GP CH were inquired. Cell viability and cellular uptake after treatment with DOX/opt CH were canvased on MCF 7, MDB-MB-231 and FaDu cell jobs. The statistical analysis of the measured replys revealed significant effects of the concentration of GO, the concentration of CS, and the CS:GP ratio on the physicochemical features of the trained GO/CS/GP CH. The optimization process ushered that DOX-laded GO/CS/GP CH developed using 0% GO and 1% CS at a CS: GO ratio of 3:1 (v/v) had the highest desirability value. DOX/opt CH expressed a porous microstructure and chemical compatibility between its components. The incorporation of GO ensued in an increase in the ability of the CH matrices to control DOX release in vitro cellular characterization showed a time-dependent increase in cytotoxicity and cellular uptake of DOX after treatment with DOX/opt CH. The offered DOX/opt CH might be seed a promising injectable platform to control the release and increase the local bioavailability of chemotherapeutics in the treatment of solid tumours. Layer-by-layer development of chitosan/alginate-free-based platelet-mimicking nanocapsules for augmenting doxorubicin cytotoxicity against breast cancer.