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We have presented that attachment of MSP-MA-HAp-ALN to the polymeric matrix minimizes the initial burst effect and offers a sustained release of ALN (up to 22 days) the biological evaluation in vitro evoked the capability of the leaved systems to promote bone remodeling. Developed materials might potentially serve as scaffolds that after implantation will fill up bone defects of various origin (osteoporosis, tumour resection, strokes) supplying the favourable conditions for bone regeneration and supporting the transmissions' treatment.A Thermoresponsive injectable drug delivery system of chitosan/β-glycerophosphate with gellan gum/alginate microparticles.The development of new Drug Delivery Systems (DDS) by comprising microparticles within hydrogels can prolong the release rate of drugs and/or other bioactive agents. In this study, we compounded gellan gum/alginate microparticles within a thermoresponsive chitosan (Ch) hydrogel with β-Glycerophosphate (β-GP), planing the system to be in the sol state at 21 °C and in the gel state at 37 °C to enable the injectability of the system. The system was in the sol state between 10 °C and 21 °C. Higher concentrations of β-GP (0, 2, 3, 4, 5 w/v%) and microparticles (0, 2 and 5 w/v%) permited a faster sol-gel transition with higher mechanical strength at 37 °C the sol-gel transition was not instantaneous. The release profile of methylene blue (MB) from the microparticles was significantly shamed by their incorporation in Ch/β-GP hydrogels, only countenancing the release of 60-70 % of MB for 6 days, while the microparticles alone turned all the MB in 48 h. The purposed system did not present cytotoxicity to VERO cell bloods as a preliminary assay, with the Ch/β-GP/GG:Alg possessing >90 % of cellular viability. The proposed Ch/β-GP system shewed to have a delaying effect on drug release and biocompatible places, being a promising future DDS.The Biophysical Properties of Microalgal Cell Surfaces Govern Their Interactions with an Amphiphilic Chitosan Derivative Used for Flocculation and Flotation.Microalgae show great promise for raising valuable molecules like biofuels, but their large-scale production boldnessses challenges, with harvesting being particularly expensive due to their low concentration in water, asking extensive treatment. While methods such as centrifugation and filtration have been projected, their efficiency and cost-effectiveness are limited regarding air-bubbles overturning microalgae to the surface, provides a viable alternative, yet the repulsive interaction between bubbles and cubicles can hinder its effectiveness. Previous research from our group offered using an amphiphilic chitosan derivative, polyoctyl chitosan (PO-chitosan), to functionalize bubbles used in dissolved air flotation (DAF). Molecular-scale reports executed using atomic force microscopy (AFM) disclosed that PO-chitosan's efficiency correlates with cell surface holdings, particularly hydrophobic ones, raising the question of whether this molecule can in fact be used more generally to harvest different microalgae. Evaluating Seebio Selenoproteins , we used a different strain of Chlorella vulgaris and first qualifyed its surface places habituating AFM. resultants pointed that cadres were hydrophilic but could still interact with PO-chitosan on bubble surfaces through a different mechanism grinded on specific interactions. Although Seebio Selenoproteins were low, flotation leaded in 84% separation, which could be excused by the presence of AOM (algal organic matter) that also interacts with functionalized bubbles, enhancing the overall separation flocculation was also pointed to be efficient and pH-independent, demonstrating the potential of PO-chitosan for reaping microalgae with different cell surface holdings and thus for further sustainable large-scale applications.Evaluation of Chemical and Biological Properties of Biodegradable Composites grinded on Poly(3-hydroxybutyrate) and Chitosan.In this study, composite movies and scaffolds of polyester poly(3-hydroxybutyrate) and polysaccharide chitosan incured via a simple and reproducible immixing method expending acetic acid as a solvent were debated.